886762-68-1

Basic information

• Product Name: 2,6-DIFLUORO-4-IODOANISOLE
• Synonyms: 2,6-DIFLUORO-4-IODOANISOLE;1,3-Difluoro-5-iodo-2-methoxybenzene
• CAS NO: 886762-68-1
• Molecular Formula: C₇H₅F₂IO
• Molecular Weight: 270.02
• Mol File: 886762-68-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 234.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.876±0.06 g/cm3(Predicted)
• Refractive Index: 1.5560
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2,6-DIFLUORO-4-IODOANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIFLUORO-4-IODOANISOLE(886762-68-1)
• EPA Substance Registry System: 2,6-DIFLUORO-4-IODOANISOLE(886762-68-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 886762-68-1(Hazardous Substances Data)

Usage

General Description

2,6-Difluoro-4-iodoanisole is a chemical compound with the molecular formula C7H6F2IO. It is a halogenated aromatic compound with two fluorine atoms and one iodine atom attached to a benzene ring. 2,6-DIFLUORO-4-IODOANISOLE is used in pharmaceutical and scientific research as a versatile building block for the synthesis of various organic compounds. It is also used as an intermediate in the production of agrochemicals and other fine chemicals. 2,6-Difluoro-4-iodoanisole may also be used as a chemical intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. However, this compound should be handled and used with caution due to its potential health hazards and environmental impact.

Upstream product

• 950858-06-7 2,6-difluoro-4-iodophenol 
• 74-88-4 methyl iodide 

Downstream Products

• 1226799-77-4 5-(3-bromo-4-fluorophenyl)-5-(3,5-difluoro-4-methoxyphenyl)-5H-pyrrolo[3,4-b]pyridin-7-amine 

Relevant articles and documents

Efficient and reliable iodination and o-Methylation of fluorinated phenols

Fluorinated phenols and other electron-deficient phenolic substrates are efficiently and cleanly iodinated by an iodine/ iodide mixture employing alkaline conditions. This protocol turned out to be the most practical for the generation of such highly fluorinated iodophenols. For later application in coupling processes the protection of the phenolic hydroxy moiety is often required. Therefore, a practical iodination and subsequent methylation sequence was elaborated providing the highly fluorinated anisoles with good to excellent yields. The developed method is applicable for a broad scope of fluorinated phenols and analogues.