886844-74-2Relevant academic research and scientific papers
Design and synthesis of potent β-secretase (BACE1) inhibitors with P1′ carboxylic acid bioisosteres
Kimura, Tooru,Hamada, Yoshio,Stochaj, Monika,Ikari, Hayato,Nagamine, Ayaka,Abdel-Rahman, Hamdy,Igawa, Naoto,Hidaka, Koushi,Nguyen, Jeffrey-Tri,Saito, Kazuki,Hayashi, Yoshio,Kiso, Yoshiaki
, p. 2380 - 2386 (2006)
Recently, we reported potent and small-sized β-secretase (BACE1) inhibitors KMI-420 and KMI-429 in which we replaced the Glu residue at the P4 position of KMI-260 and KMI-360, respectively, with a 1H-tetrazole-5-carbonyl DAP (l-α,β-diaminopropi
