886974-10-3Relevant academic research and scientific papers
One-pot Pd-catalyzed hydrostannation/Stille reaction with acid chlorides as the electrophiles
Lee, Kyoungsoo,Gallagher, William P.,Toskey, Elli A.,Chong, Wenzheng,Maleczka Jr., Robert E.
, p. 1462 - 1465 (2006)
A one-pot hydrostannation/Stille coupling sequence amenable to the employment of acid chloride electrophiles has been developed. In this protocol, palladium mediated alkyne hydrostannations using Me3SnF/PMHS as an in situ trimethyltin hydride source are followed by the addition of the acid chloride to afford a variety of α,β-unsaturated ketones in a single pot.
