886979-81-3

Basic information

• Product Name: 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-
• Synonyms: 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-;N-((S)-1-(((S)-1-hydroperoxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide;Bortezomib Impurity 13;Bortezomib Impurity 4;(S)-Hydroperoxy Des(boric Acid) Bortezomib;Bortezomib Impurity 47;N-[(2S)-1-[[(1S)-1-hydroperoxy-3-methylbutyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide;Bortezomib USP Related Compoud M
• CAS NO: 886979-81-3
• Molecular Formula: C19H24N4O4
• Molecular Weight: 372.41826
• EINECS: -0
• Mol File: 886979-81-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 709.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.227±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• PKA: 10.96±0.10(Predicted)
• Stability: Unstable in Methanol
• CAS DataBase Reference: 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-(886979-81-3)
• EPA Substance Registry System: 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-(886979-81-3)

Safety Data

• Hazardous Substances Data: 886979-81-3(Hazardous Substances Data)

Usage

Description

2-Pyrazinecarboxamide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]is a complex organic compound with a unique molecular structure. It is characterized by the presence of a pyrazine carboxamide core, a chiral center at the 1S position, and a hydroperoxy-3-methylbutyl group attached to an amino function. Additionally, it features a phenylmethyl substituent, which contributes to its overall chemical properties and potential applications.

Uses

Used in Pharmaceutical Industry:
2-Pyrazinecarboxamide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]is used as an impurity in the development and manufacturing of Bortezomib (B675700). Bortezomib is the first proteasome inhibitor to be approved by the US FDA for the treatment of multiple myeloma, a type of blood cancer. The presence of this compound as an impurity is crucial for understanding the purity and quality of Bortezomib, ensuring the safety and efficacy of the drug for patients.
As an impurity, 2-Pyrazinecarboxamide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]plays a significant role in the pharmaceutical industry, particularly in the development and production of Bortezomib. Its presence helps researchers and manufacturers maintain the highest standards of drug quality, ultimately benefiting patients receiving treatment for multiple myeloma.