886983-45-5

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 149104-88-1 4-methanesulphonylphenylboronic acid 

Downstream Products

• 1313397-33-9 5-((5-(4-(methylsulfonyl)phenyl)thiophen-2-yl)methylene)-2-thioxoimidazolidin-4-one 
• 1026889-26-8 (E)-3-[5-(4-methylsulfonylphenyl)-2-thienyl]acrylic acid chloride 

Relevant academic research and scientific papers

COMPOUNDS, PREPARATIONS AND USES THEREOF

The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susc

Non-thiol farnesyltransferase inhibitors: Utilization of the far aryl binding site by arylthienylacryloyl-aminobenzophenones

We recently described two novel aryl binding sites of farnesyltransferase. The 4- and 5-arylsubstituted thienylacryloyl moieties turned out as appropriate substituents for our benzophenone-based AAX-peptidomimetic capable for occupying the far aryl binding site.

Structure-activity relationships of novel anti-malarial agents part 8. Effect of different central aryls in biarylacryloylaminobenzophenones on antimalarial activity

Replacement of the 2,5-disubstituted furyl residue present in the known antimalarial agents 8 by other aryl residues resulted in a more or less reduced antimalarial activity in most cases. The only exemption was the 2,4-thienylene compound 11a displaying activity with an IC50 value of 120 nM. In conclusion, the 2,5-furylene compound 8e remains to represent the most active antimalarial agent in this series of farnesyltransferase inhibitors.