886984-31-2

Upstream product

• 497066-72-5 5-Acetyl-6-methyl-4-(3-nitro-phenyl)-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile 
• 106-89-8 epichlorohydrin 

Relevant academic research and scientific papers

Synthesis and properties of 7-acetyl-8-aryl-9-cyano-3-hydroxy-6-methyl-3,4- dihydro-2H,8H-pyrido[2,1-6][1,3]thiazines

7-Acetyl-8-aryl-2-(1-chloro-2-hydroxy-3-propyl)thio-9-cyano-6-methyl-1, 4-dihydropyndines were obtained by treatment of 1,4-dihydropyridine-2(3H)- thiones with epichlorohydrin in the presence of sodium bicarbonate. When treated with NaOMe, these compounds are readily intramolecularly alkylated with formation of 7-acetyl-8-aryl-3-hydroxy-9-cyano-6-methyl-3,4-dihydro-2H,8H- pyrido[2,1-b]-[1,3]thiazines. We have studied amination of 2-(1-chloro-2- hydroxy-3-propyl)thio-1,4-dihydropyridines and acylation of 3-hydroxy-3,4- dihydro-2H,8H-pyrido[2,1-b][1,3]thiazines. 2005 Springer Science+Business Media, Inc.