886984-76-5Relevant academic research and scientific papers
Bioactivity profiling using HPLC/microtiter-plate analysis: Application to a New Zealand marine alga-derived fungus, gliocladium sp.
Lang, Gerhard,Mitova, Maya I.,Ellis, Gill,Van Der Sar, Sonia,Phipps, Richard K.,Blunt, John W.,Cummings, Nicholas J.,Cole, Anthony L. J.,Munro, Murray H. G.
, p. 621 - 624 (2008/09/20)
Using HPLC/microtiter-plate-based generation of activity profiles the extract of a marine alga-derived fungus, identified as Gliocladium sp., was shown to contain the known strongly cytotoxic metabolite 4-keto-clonostachydiol (1) and also clonostachydiol (2) as well as gliotide (3), a new cyclodepsipeptide containing several D-amino acids. The absolute configuration of 1 was elucidated by reduction to 2, and two further oxidized derivatives of clonostachydiol (5, 6) were prepared and evaluated for biological activity.
