88700-89-4

Upstream product

• 113616-57-2 5-Acetoxy-2,6-dibromo-hexanoic acid methyl ester 
• 119873-57-3 (2S,5R)-5-Acetoxymethyl-tetrahydro-furan-2-carboxylic acid methyl ester 
• 2144-40-3 cis-2,5-bis(hydroxymethyl)tetrahydrofuran 
• 119873-51-7 (+/-)-[(2S,5R)-tetrahydrofuran-2,5-diyl]bis(methyl) diacetate 
• 92383-44-3 (2R,5S)-(-)-2-(acetoxymethyl)-5-(hydroxymethyl)tetrahydofuran 
• 104-80-3 tetrahydrofuran-2,5-dimethanol 
• 142824-48-4 Benzoic acid (2S,5R)-5-cyano-tetrahydro-furan-2-ylmethyl ester 
• 127676-65-7 C₂₀H₁₅NO₅ 
• 14257-69-3 glucosamine 
• 142824-49-5 (2R,5S)-5-Benzoyloxymethyl-tetrahydro-furan-2-carboxylic acid 

Relevant academic research and scientific papers

Preparation of Tetrahydrofurfuryl Alcohol Derivatives with Electron-Withdrawing Substituents from 4-Acetoxy-1,5-dibromopentane Derivatives

When 4-acetoxy-1,5-dibromopentane derivatives having the electron-withdrawing groups at the 1-position, which were obtained by Cu(I)-catalyzed photochemical addition of 2-acetoxy-1,3-dibromopropane to electron-deficient olefins, were subjected to treatment with silver nitrate, tetrahydrofurfuryl alcohol derivatives with the electron-withdrawing groups at the 5-position were obtained.

CONVERSION OF 1,2,5,6-HEXANETETROL (HTO) TO TETRAHYDROFURAN DICARBOXYLIC ACID (THFDCA)

Disclosed herein are methods for synthesizing useful intermediates and/or products from 1,2,5,6-hexanetetrol (HTO), which itself can be derived from a sugar. In an aspect, a process is provided for production of THFDCA from 1,2,5,6-hexanetetrol (HTO). The process comprises the steps of (a) ring closing to form a ring compound and (b) oxidizing using a catalyst comprising platinum and bismuth to form an acid mixture. Step (a) may be performed before or after step (b).

Efficient Synthesis of 2',3'-Dideoxynucleosides and 2',3'-Dideoxy C-Nucleosides from D-Glucosamine

D-Glucosamine 1 can be easily converted into 2,5-anhydro-6-O-benzoyl-3,4-dideoxygluconic acid 6 which can be taken on to both 2',3'-dideoxynucleosides such as dideoxyuridine (ddU) 4 and 2',3'-dideoxy C-nucleosides such as dideoxyformycin B 5 and dideoxyshowdomycin 20.

Enzyme-catalyzed Asymmetric Hydrolysis of meso-Substrate. The Facile Synthesis of Both Enantiomers of cis-2,5-Disubstituted Tetrahydrofuran Derivatives

The enzyme-catalyzed asymmetric hydrolysis of the meso-diesters derived from cis-2,5-bis(hydroxymethyl)tetrahydrofuran in presence of PLE, PPL, and CCL afforded the optically active half-esters.The both enantiomers of cis-5-(hydroxymethyl)tetrahydrofuran-2-carboxylic acid with high optical purity were prepared from the half-esters.