887113-20-4

Upstream product

• 505-23-7 1,3 dithiane 
• 153277-49-7 (S)-N-benzylidene-4-toluenesulfinamide 
• 36049-90-8 2-lithio-1,3-dithiane 
• 350479-90-2 (S,E)-N-benzylidene-4-methylbenzenesulfinamide 

Downstream Products

• 118917-60-5 (S)-N-(2-hydroxy-1-phenylethyl)-4-methylbenzenesulfonamide 
• 887113-24-8 N-([1,3]dithian-2-yl-phenyl-methyl)-4-methyl-benzenesulfonamide 
• 887113-22-6 (S)-2-phenyl-2-(tosylamino)acetaldehyde 
• 887113-23-7 C-[1,3]dithian-2-yl-C-phenyl-methylamine 

Relevant academic research and scientific papers

Asymmetric synthesis of N-tosyl amino acids from N-sulfinyl α-amino-1,3-dithioketals

Hydrolysis of diastereomerically pure N-sulfinyl α-amino-1,3- dithianes with 1,3-dibromo-5,5-dimethylhydantoin gives N-tosyl α-amino aldehydes which when subjected to a Pinnick-type oxidation gave N-tosyl α-amino acids without epimerization.

Asymmetric synthesis of α-amino aldehydes from sulfinimine (N-sulfinyl imine)-derived α-amino 1,3-dithianes. Formal synthesis of (-)-2,3-trans-3,4-cis-dihydroxyproline

Hydrolysis of sulfinimine-derived N-sulfinyl α-amino 1,3-dithianes with aqueous 1,3-dibromo-5,5-dimethylhydantoin affords the corresponding N-tosyl α-amino aldehydes in good yield and high enantiomeric purity. These aldehydes can be reduced to amino alcoh