887138-02-5Relevant articles and documents
Selective Synthesis of Acylated Cross-Benzoins from Acylals and Aldehydes via N-Heterocyclic Carbene Catalysis
Onodera, Kou,Suzuki, Yumiko,Takashima, Ryo
supporting information, p. 4197 - 4202 (2021/06/27)
The utility of acylals as building blocks for selective cross-benzoin synthesis was explored in this study. The synthesis of α-acetoxyketones (O-acyl cross-benzoins) was achieved via selective N-heterocyclic carbene-catalyzed cross-benzoin reactions using acylals as aldehyde equivalents. Thus, the combination of ortho-substituted phenyl acylals and aromatic/aliphatic aldehydes as coupling substrates using bicyclic triazolium salts as precatalysts and potassium carbonate as a base in THF at reflux temperature selectively yielded O-acyl cross-benzoins.
SnCl2.2H2O and Ni(OAc)2.4H2O: Efficient heterogeneous inorganic catalysts for the chemoselective synthesis of geminal diacetates (acylal) under solvent-free conditions
Khazaei, Ardeshir,Manesh, Abbas Amini,Alavi-Nik, Heidar Ali,Roosta, Zahra Toodeh
experimental part, p. 627 - 630 (2011/12/15)
SnCl2.2H2O and Ni(OAc)2.4H2O were found to be efficient catalysts for preparation of 1,1-diacetates under solvent-free conditions at room temperature. Easy work-up and low cost are important features from the environmental and economical points of view, are distinct aspects of this research. Very good to exellent yields, short reaction times, non-toxicity and stability of the catalysts are noteworthy advantages of this method.
Cobalt-catalyzed addition of azoles to alkynes
Ding, Zhenhua,Yoshikai, Naohiko
supporting information; experimental part, p. 4180 - 4183 (2010/11/19)
A ternary catalytic system consisting of a cobalt salt, a diphosphine ligand, and a Grignard reagent promotes syn-addition of an azole C(2)-H bond across an unactivated internal alkyne with high chemo-, regio-, and stereoselectivities under mild conditions. Mechanistic experiments suggest that the reaction involves oxidative addition of the oxazolyl C-H bond to the cobalt center, alkyne insertion into the Co-H bond, and reductive elimination of the resulting diorganocobalt species.
