887147-34-4Relevant academic research and scientific papers
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: Synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis
Dyckman, Alaric J.,Langevine, Charles M.,Quesnelle, Claude,Kempson, James,Guo, Junqing,Gill, Patrice,Spergel, Steven H.,Watterson, Scott H.,Li, Tianle,Nirschl, David S.,Gillooly, Kathleen M.,Pattoli, Mark A.,McIntyre, Kim W.,Chen, Laishun,McKinnon, Murray,Dodd, John H.,Barrish, Joel C.,Burke, James R.,Pitts, William J.
scheme or table, p. 383 - 386 (2011/02/27)
The synthesis, structure-activity relationships (SAR) and biological evaluation of thiazole based tricyclic inhibitors of IKK2 are described. Compound 9 was determined to be orally efficacious in a murine model of rheumatoid arthritis.
8H-IMIDAZO[4,5-D]THIAZOLO[4,5-B]PYRIDINE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
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Page/Page column 72-73, (2008/06/13)
The present invention provides for thiazolopyridine-based tricyclic compounds having the formula (I) wherein R1, R2, R5 and R6 are as described herein. The present invention further provides pharmaceutical compo
