88722-28-5Relevant academic research and scientific papers
Anti-aids agent potentiators Cobicistat key intermediate in the preparation method of the hydrochloric acid salt (by machine translation)
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Paragraph 0082; 0083, (2017/05/03)
The present invention provides a compound of formula (V) shown in the key intermediate Cobicistat process for the preparation of hydrochloride: to formula (I) selective amino protection shown in L-Phenylalaninol as the starting material, the sulfonic acid
An Unusual Acyliminium Cyclization and Other Drawbacks during an Attempted Synthesis of a Chiral Primary α-Phosphinoalkanamine
Christoffers, Jens
, p. 845 - 852 (2007/10/03)
Studies towards the synthesis of a chiral primary α-phosphinoalkanamine 1a are reported. O-Activated, N-carbamate-protected phenylalaninol 3a did not undergo 5N reaction with KPPh2: instead, after TV-deprotonalion, intramolecular substitution led to formation of the aziridine derivative 5a (Scheme 2). N-Phthalimido-protected. O-activated phenylalaninol 3b also underwent an intramolecular process on treatment with KPPh2, i.e., an unusual aryl-acyliminium cyclization furnishing the (epoxymethano)isoindolo[1,2-a]isoquinolinone 7 (Scheme 3). In a reaction with KPPh2, the N,N-dibenzyl-protected and activated phenylalaninol 3d finally yielded the intermolecular SN reaction product 2a (Scheme 4). However, debenzylation by catalytic hydrogenation turned out to be impossible.
Syntheses and Investigations of isoindol-9b(2H)-yl>phosphinates and -phosphonates: a New Class of Heterocycles
Neidlein, Richard,Greulich, Peter,Kramer, Walter
, p. 2407 - 2417 (2007/10/02)
We attempted to synthesize diethyl (1-methyl-2-phthalimidoethyl)phosphonate (14a) in a Michaelis-Becker reaction using diethyl sodiophosphonate (13) and the tosylate 12a of (2-hydroxypropyl)phthalimide as starting materials.Instead of TsO substitution in
