887263-00-5Relevant academic research and scientific papers
Reactions of substituted ethyl 1,2,3,4,4′,5′-hexahydrospiro- [naphthalene-2,5′-pyrazole]-3′-carboxylates with halogens
Molchanov,Korotkov,Kopf,Kostikov
, p. 1036 - 1042 (2005)
Substituted ethyl 1,2,3,4,4′,5′-hexahydrospiro[naphthalene-2, 5′-pyrazole]-3′-carboxylates react with chlorine or N-bromosuccinimide to give spirocyclic substituted 3-halo-4,5-dihydro-3H- pyrazoles which lose nitrogen molecule on heating with formation of substituted spirocyclic 1-halocyclopropane-1-carboxylates. Heating of the title compounds with bromine in acetic acid results in opening of the spiro-fused six-membered ring to afford ethyl 4-aryl-5-[2-(2-carboxyphenyl)ethyl]pyrazole-3-carboxylates.
