887268-36-2

Basic information

• Product Name: 1-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)benzene, 4-Fluorophenyl 1,1,2,2-tetrafluoroethyl ether
• Synonyms: 1-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)benzene, 4-Fluorophenyl 1,1,2,2-tetrafluoroethyl ether;alpha,alpha,beta,beta,4-Pentafluorophenetole
• CAS NO: 887268-36-2
• Molecular Formula: C₈H₅F₅O
• Molecular Weight: 212.116716
• Mol File: 887268-36-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)benzene, 4-Fluorophenyl 1,1,2,2-tetrafluoroethyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)benzene, 4-Fluorophenyl 1,1,2,2-tetrafluoroethyl ether(887268-36-2)
• EPA Substance Registry System: 1-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)benzene, 4-Fluorophenyl 1,1,2,2-tetrafluoroethyl ether(887268-36-2)

Safety Data

• Hazardous Substances Data: 887268-36-2(Hazardous Substances Data)

Usage

General Description

1-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)benzene and 4-Fluorophenyl 1,1,2,2-tetrafluoroethyl ether are two organic chemicals commonly used in the production of pharmaceuticals, agrochemicals, and materials science. The first chemical, 1-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)benzene, is a fluorinated aromatic compound with a fluorine atom and tetrafluoroethoxy group attached to a benzene ring, while the 4-Fluorophenyl 1,1,2,2-tetrafluoroethyl ether is an ether derivative with a tetrafluoroethyl group and a fluorophenyl group. Both chemicals are valued for their use as versatile intermediates in synthetic chemistry, allowing for the creation of a wide range of compounds for various applications.

Upstream product

• 2032375-46-3 C₈H₄BrF₅O 

Relevant articles and documents

Nucleophilic tetrafluoroethylation employing in situ formed organomagnesium reagents

Tetrafluoroalkyl bromides are metalated with equimolar iPrMgCl·LiCl (Turbo Grignard) to form organomagnesium compounds which are stable at low temperatures and react with various electrophiles (aldehydes, ketones, CO2, cyclic sulfate and sulfamidate, N-sulfonylimines, nitrone, chlorophosphate, nonaflyl azide) to afford novel functionalized tetrafluoroethylene-containing products. Ease of operation, excellent selectivity, high nucleophilicity, and enhanced stability of the reactive species together with a broad substrate scope comprise a highly attractive nucleophilic tetrafluoroethylation protocol affording unique synthetic building blocks.