887279-55-2Relevant academic research and scientific papers
A Novel Approach to Pyrrolo[2,1-b]thiazoles
Tverdokhlebov, Anton V.,Resnyanska, Elizaveta V.,Tolmachev, Andrey A.,Andrushko, Alexander P.
, p. 2632 - 2638 (2003)
5-Aroyl-2-(dimethylamino)methylidene-2,3-dihydro-3-oxopyrrolo[2,1-b] thiazole-7-carboxylic acid esters, -7-carbonitriles and corresponding 7-hetaryl substituted derivatives were prepared. Thus, the substituted acetonitriles (XCH2CN, where X = CO2R, CN, hetaryl) were treated with mercaptoacetic acid yielding 2-(X-methylidene)thiazolidin-4-ones, which were N-alkylated with phenacyl bromides. Further formylation of the obtained compounds with excess of DMF·POCl3 complex led to the above mentioned pyrrolo[2,1-b]thiazoles.
