88729-93-5Relevant academic research and scientific papers
Chromium tricarbonyl complexes of estradiol derivatives: Differentiation of α- and β-diastereoisomers using one- and two-dimensional NMR spectroscopy at 500 MHz
Top, Siden,Jaouen, Gérard,Vessières, Anne,Abjean, Jean-Pierre,Davoust, Daniel,Rodger, Charles A.,Sayer, Brian G.,McGlinchey, Michael J.
, p. 2143 - 2150 (2008/10/08)
The steroidal hormone β-estradiol and its derivatives in which the hydroxyl functionalities have been protected by benzyl or dimethyl-tert-butylsilyl groups bond to a tricarbonylchromium moiety via either the α- or the β-face of the arene ring. Unambiguous differentiation of these diastereomers is difficult without recourse to X-ray crystallographic techniques. These molecules have been characterized by 500-MHz 1H and 125-MHz 13C NMR spectroscopy; assignments are made by using the two-dimensional techniques COSY and SECSY as well as heteronuclear shift-correlated spectra. Thus, high field NMR spectroscopy provides a straightforward method of differentiating between the α- and β-isomers.
