887401-28-7Relevant academic research and scientific papers
Starving the malaria parasite: Inhibitors active against the aspartic proteases plasmepsins I, II, and IV
Hof, Fraser,Schuetz, Andri,Faeh, Christoph,Meyer, Solange,Bur, Daniel,Liu, Jun,Goldberg, Daniel E.,Diederich, Francois
, p. 2138 - 2141 (2007/10/03)
Clamping down: A new class of aspartic protease inhibitors that target the malarial protease family Plasmepsin are reported. These ligands utilize a novel "diamine clamp" to engage the catalytic dyad. They are potent inhibitors of plasmepsins I, II, and IV, while retaining good selectivity against the closely related human cathepsins D and E. (Chemical Equation Presented) .
