887469-92-3Relevant academic research and scientific papers
Investigation of the asymmetric Birch reduction-alkylation of a chiral 5-arylbenzamide containing a carbamate group
Casimiro-Garcia, Agustin,Schultz, Arthur G.
, p. 2739 - 2742 (2006)
The synthesis and asymmetric Birch reduction-alkylation of chiral benzamide 17 are described. Birch reductive alkylation of benzamide 17 was optimized to give the corresponding cyclohexa-1,4-diene products in 66-78% isolated yield and with high diastereoselectivity (dr: >98:2). The effects of performing the reduction in the presence and in the absence of tert-butyl alcohol are discussed.
