887567-77-3Relevant academic research and scientific papers
Fast degenerate double proton transfer in the solid state between two indazolinone tautomers
Perez-Torralba, Marta,Lopez, Concepcion,Perez-Medina, Carlos,Claramunt, Rosa M.,Pinilla, Elena,Torres, M. Rosario,Alkorta, Ibon,Elguero, Jose
, p. 4052 - 4055 (2010)
The neutral dimer formed by 4,6-difluoro-1H,2H-indazolin-3-one and 3-hydroxy-4,6-difluoro-1H-indazole linked by two hydrogen bonds presents a very fast intermolecular double proton transfer in the solid state (ISSPT). The combined use of crystallography, solid state NMR and DFT [B3LYP/6-311++G(d,p)] calculations supports this interesting observation and allows us to estimate a barrier of about 20 kJ mol-1.
Synthesis and biological evaluation of indazole derivatives
Claramunt, Rosa M.,López, Concepción,López, Ana,Pérez-Medina, Carlos,Pérez-Torralba, Marta,Alkorta, Ibon,Elguero, José,Escames, Germaine,Acu?a-Castroviejo, Darío
, p. 1439 - 1447 (2011/04/24)
The inhibition of neuronal and inducible nitric oxide synthases (nNOS and iNOS) by a series of 36 indazoles has been evaluated, showing that most of the assayed derivatives are better iNOS than nNOS inhibitors. A parabolic model relating the iNOS inhibiti
