887584-39-6

Basic information

• Product Name: 3-amino-3-phenyl-2-pyridin-2-ylacrylonitrile
• Synonyms: 3-amino-3-phenyl-2-pyridin-2-ylacrylonitrile
• CAS NO: 887584-39-6
• Molecular Formula: C14H11N3
• Molecular Weight: 221.25724
• Mol File: 887584-39-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-amino-3-phenyl-2-pyridin-2-ylacrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-3-phenyl-2-pyridin-2-ylacrylonitrile(887584-39-6)
• EPA Substance Registry System: 3-amino-3-phenyl-2-pyridin-2-ylacrylonitrile(887584-39-6)

Safety Data

• Hazardous Substances Data: 887584-39-6(Hazardous Substances Data)

Upstream product

• 22345-98-8 3-phenyl-2-(pyridin-2-yl)acrylonitrile 
• 2739-97-1 pyridine-2-acetonitrile 
• 100-47-0 benzonitrile 

Relevant articles and documents

Transition-metal-switchable divergent synthesis of nitrile-containing pyrazolo[1,5-a]pyridines and indolizines

Palladium-catalyzed oxidative formal [4 + 1] annulation of pyridine-substituted acrylonitriles toward divergent fused N-heterocycles synthesis is reported. The heterodifunctionalization reaction with Cu(OAc)2 and urea as the nitrogen source accesses to nitrile-substituted pyrazolo[1,5-a]pyridines in moderate to good yields, while the homodifunctionalization reaction with FeBr3 leads to synthesis of nitrile-substituted indolizines in excellent yields.

Temperature controlled condensation of nitriles: Efficient and convenient synthesis of β-enaminonitriles, 4-aminopyrimidines and 4-amidinopyrimidines in one system

A series of β-enaminonitriles, 4-aminopyrimidines and 4-amidinopyrimidines were synthesized by condensation of organonitriles in one system. A wide variety of compounds were obtained in good to excellent yields by simply controlling the reaction temperature. The base-induced transformation process is easy for production. The scope and versatility of the method have been successfully demonstrated with 72 examples. The flexible and diversified characteristics of nitriles were introduced based on electronic effect, steric effect, position of substituted groups and intermolecular hydrogen bonding. An updated reaction mechanism is proposed based on the study of the stoichiometric reaction conditions at variable temperature, and on the investigation of products with cis-trans configuration transformation.

Synthesis of 2 H-Azirines via Iodine-Mediated Oxidative Cyclization of Enamines

A facile and practical oxidative cyclization reaction of enamines to 2H-azirines has been developed, employing molecular iodine. The features of the present synthetic approach include no use of transition metals, mild reaction conditions, and simplicity o