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Usage

Uses

Used in Pharmaceutical Industry:
1-Boc-3-methylazetidine-3-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those containing azetidine-3-carboxylic acid moieties. Its protected structure allows for efficient and selective reactions, facilitating the production of desired drug candidates.
Used in Organic Synthesis:
In the field of organic synthesis, 1-Boc-3-methylazetidine-3-carboxylic acid is employed as a versatile building block for the preparation of complex organic molecules. Its unique structural features enable the formation of diverse chemical entities, making it a valuable component in the synthesis of bioactive compounds and other specialty chemicals.
Used in Research and Development:
1-Boc-3-methylazetidine-3-carboxylic acid is utilized in research and development settings to explore its potential applications and properties. Scientists and chemists investigate its reactivity, stability, and interactions with other molecules to uncover new insights and applications in various fields, such as materials science, medicinal chemistry, and chemical biology.

Upstream product

• 142253-54-1 tert-butyl 3-cyanoazetidine-1-carboxylate 
• 254454-54-1 tert-butyl-3-iodoazetidine-1-carboxylate 
• 936850-09-8 tert-butyl 3-cyano-3-methylazetidine-1-carboxylate 
• 142253-55-2 1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 1363382-91-5 3-hydroxymethyl-3-methyl-azetidine-1-carboxylic acid tert-butyl ester 
• 1613718-13-0 (R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one 
• 1613720-93-6 3-{(R)-1-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]ethyl}-3-methylazetidine-1-carboxylic acid tert-butyl ester 
• 1632328-84-7 (R)-6-[(R)-1-(1,3-dimethylazetidin-3-yl)ethyl]-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one 
• 1114876-08-2 methyl 3-methylazetidine-3-carboxylate hydrochloride 
• 898228-37-0 3-methyl-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester 

Relevant academic research and scientific papers

An improved, gram-scale synthesis of protected 3-haloazetidines: Rapid diversified synthesis of azetidine-3-carboxylic acids

Azetidines are increasingly important heterocycles found in a variety of natural products and pharmaceutical compounds. Protected 3-haloazetidines, widely used and versatile building blocks in medicinal chemistry, have been prepared in a one-pot, gram-scale strain-release reaction of 1-azabicyclo[1.1.0]butane from commercially available starting materials. These intermediates were subsequently used to prepare a series of high value azetidine-3-carboxylic acid derivatives including the first reported synthesis of 1-(tert-butoxy-carbonyl)-3-((trifluoromethyl)thio)azetidine-3-carboxylic acid. (Figure pressented)

NOVEL PYRIDINE COMPOUNDS

The present invention relates to certain novel pyridin compounds of Formula ( I ) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, and processes for their preparation, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.