88775-23-9

Upstream product

• 135-77-3 1,2,4-trimethoxy-benzene 
• 4460-86-0 asaraldehyde 
• 6329-73-3 1-benzo[1,3]dioxol-5-yl-ethanol 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 120-57-0 piperonal 
• 151-50-8 potassium cyanide 
• 88775-43-3 (E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one 

Downstream Products

• 88775-26-2 4-(3,4-methylenedioxyphenyl)-4-oxo-2-(2,4,5-trimethoxyphenyl)butyric acid 
• 88775-27-3 4-(3,4-methylenedioxyphenyl)-2-(2,4,5-trimethoxyphenyl)butyric acid 
• 88775-70-6 6,7-methylenedioxy-2-(2,4,5-trimethoxyphenyl)-3,4-dihydronaphthalen-1(2H)-one 

Relevant academic research and scientific papers

Studies on the chemical constituents of rutaceous plants. XLIX. Development of a versatile method for the synthesis of antitumor-active benzo[c]phenanthridine alkaloids. (1). Preparation of various 2,4-bisaryl-4-oxobutyronitriles and 2,4-bisaryl-4-oxobutyramides

For the sake of establishment of a versatile synthetic method for benzo[c]phenanthridine alkaloids, improvement of the Robinson synthetic method was examined. Thirteen chalcones (7a-m) were prepared by condensation of two acetophenone derivatives (15 and 16) with eleven benzaldehyde derivatives (19a-k) as fundamental starting materials. Hydrocyanation of these chalcones (7a-1) except one (7m) gave the corresponding 2,4-bisaryl-4-oxobutyronitriles (8a-1). Eleven 2,4-bisaryl-4-oxobutyramides (9a-k) were also prepared.