887757-23-5

Basic information

• Product Name: N-(2-bromo-5-methylphenyl)-N-methylacetamide
• Synonyms: N-(2-bromo-5-methylphenyl)-N-methylacetamide
• CAS NO: 887757-23-5
• Molecular Weight: 242.115
• Mol File: 887757-23-5.mol

Chemical Properties

• CAS DataBase Reference: N-(2-bromo-5-methylphenyl)-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-bromo-5-methylphenyl)-N-methylacetamide(887757-23-5)
• EPA Substance Registry System: N-(2-bromo-5-methylphenyl)-N-methylacetamide(887757-23-5)

Safety Data

• Hazardous Substances Data: 887757-23-5(Hazardous Substances Data)

Upstream product

• 53078-85-6 2-bromo-5-methylaniline 
• 887757-24-6 3-[acetyl(methyl)amino]-4-bromobenzoic acid 
• 126759-48-6 N-(2-bromo-5-methylphenyl)acetamide 
• 74-88-4 methyl iodide 

Relevant articles and documents

Heterogeneous palladium-catalysed intramolecular C(sp3)[sbnd]H α-arylation for the green synthesis of oxindoles

Herein, we present our results on the development of a waste-minimized protocol for the synthesis of oxindoles using cyclopentyl methyl ether (CPME) as a safe and green reaction medium and palladium on carbon (Pd/C) as a reusable catalyst. This protocol is efficiently applied to a variety of substrates affording products with excellent yields, minimal metal contamination and minimum waste production. The catalyst was recovered and reused for four consecutive runs without any apparent loss of efficiency. Moreover, products were isolated by simple precipitation from heptane with no need for chromatographic separations, and both CPME and heptane were recovered. Waste-minimization is reflected by the low E-factor calculated for the presented protocol.

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) , or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

A 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented by the generalformula (1): [Chemical formula 1] (1) or a pharmaceutically acceptable saltthereof. They are useful as a therapeutic/preventive agent for diabetes, diabeticnephropathy, or glomerulosclerosis.