887903-73-3

Basic information

• Product Name: 2-(2,6-dichloro-benzenesulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carboxylic acid ethyl ester
• CAS NO: 887903-73-3
• Molecular Weight: 392.303
• Mol File: 887903-73-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2,6-dichloro-benzenesulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-dichloro-benzenesulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carboxylic acid ethyl ester(887903-73-3)
• EPA Substance Registry System: 2-(2,6-dichloro-benzenesulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carboxylic acid ethyl ester(887903-73-3)

Safety Data

• Hazardous Substances Data: 887903-73-3(Hazardous Substances Data)

Upstream product

• 6579-54-0 2,6-dichlorobenzenesulfonyl chloride 
• 385808-61-7 ethyl 2-azabicyclo[2.2.2]octane-3-carboxylate 

Downstream Products

• 887907-16-6 (S)-2-{[2-(2,6-Dichloro-benzenesulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-3-(4-nitro-phenyl)-propionic acid methyl ester 
• 887907-17-7 (S)-3-(4-Amino-phenyl)-2-{[2-(2,6-dichloro-benzenesulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-propionic acid methyl ester 
• 887903-74-4 2-(2,6-dichloro-benzenesulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carboxylic acid 

Relevant articles and documents

Aza-bicyclic amino acid sulfonamides as α4β 1/α4β7 integrin antagonists

The design, synthesis, and biological activity of novel α 4β1 and α4β7 integrin antagonists, containing a bridged azabicyclic nucleus, are reported. Conformational analysis of targets containing an azabicyclo[2.2.2]octane carboxylic acid and known integrin antagonists indicated that this azabicycle would be a suitable molecular scaffold. Variation of substituents on the pendant arylsulfonamide and phenylalanine groups resulted in potent α 4β1-selective and dual α4β 1/α4β7 antagonists. Potent compounds 11i, 11h, and 14 were effective in the antigen-sensitized sheep model of asthma. 2003 Elsevier Science Ltd. All rights reserved.