88796-46-7Relevant academic research and scientific papers
Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-RafV600E kinase with favorable physicochemical and pharmacokinetic properties
Ren, Li,Laird, Ellen R.,Buckmelter, Alex J.,Dinkel, Victoria,Gloor, Susan L.,Grina, Jonas,Newhouse, Brad,Rasor, Kevin,Hastings, Gregg,Gradl, Stefan N.,Rudolph, Joachim
scheme or table, p. 1165 - 1168 (2012/03/11)
Herein we describe a novel series of ATP competitive B-Raf inhibitors based on the pyrazolo[1,5-a]pyrimidine scaffold. These inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. Optimization led to the identification of compound 17, a potent, selective and orally available agent with improved physicochemical and pharmacokinetic properties.
RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF
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Page/Page column 49, (2011/04/14)
Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment
5,6-CONDENSED 3-NITROPYRIDINES FROM HETEROCYCLIC AMINES AND NITROMALONALDEHYDE
Schaefer, H.,Gewald, K.,Schmidt, M.
, p. 1163 - 1166 (2007/10/02)
The reaction of nitromalonaldehyde with 2-aminothiophenes leads to 5-nitrothienopyridines.The analogous reaction with 3-aminopyrroles leads to 6-nitropyrrolopyridines.The analogous reaction with 4- and 5-aminopyrazoles leads to 6-nitropyrazo
