887979-15-9Relevant academic research and scientific papers
Design, synthesis and biological evaluation of isoxazole-containing biphenyl derivatives as small-molecule inhibitors targeting the programmed cell death-1/ programmed cell death-ligand 1 immune checkpoint
Wang, Lixun,Yang, Yifei,Zhang, Huibin,Zhang, Jian,Zhou, Jinpei,Zhu, Peiyu
, (2021)
Monoclonal antibodies targeting the programmed cell death-1/ programmed cell death-ligand 1 (PD-1/PD-L1) immune checkpoint have achieved enormous success in cancer immunotherapy. But the antibody-based immunotherapies carry a number of unavoidable deficie
