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6-(4-Trifluoromethoxyphenyl)-picolinic acid is a chemical compound belonging to the picolinic acid family, characterized by a molecular formula of C13H9F3NO3. It is a white to off-white powder that demonstrates solubility in dimethyl sulfoxide and dimethylformamide. 6-(4-Trifluoromethoxyphenyl)-picolinic acid is distinguished by its unique structure and properties, which include anti-inflammatory and antioxidative activities, positioning it as a promising candidate for pharmaceutical research and development.

887982-16-3

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887982-16-3 Usage

Uses

Used in Pharmaceutical Industry:
6-(4-Trifluoromethoxyphenyl)-picolinic acid is utilized as a building block for the synthesis of various drug molecules, capitalizing on its chemical properties to create new therapeutic agents. Its potential lies in the treatment of inflammatory diseases and oxidative stress-related disorders, given its reported anti-inflammatory and antioxidative properties.
Used in Drug Development:
As a valuable tool for researchers and drug developers, 6-(4-Trifluoromethoxyphenyl)-picolinic acid aids in the pursuit of novel therapeutic agents. Its unique structure allows for the exploration of its potential in treating a range of conditions, making it an important component in the advancement of pharmaceutical innovation.

Check Digit Verification of cas no

The CAS Registry Mumber 887982-16-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,7,9,8 and 2 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 887982-16:
(8*8)+(7*8)+(6*7)+(5*9)+(4*8)+(3*2)+(2*1)+(1*6)=253
253 % 10 = 3
So 887982-16-3 is a valid CAS Registry Number.

887982-16-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-[4-(trifluoromethoxy)phenyl]pyridine-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names 6-(4-(Trifluoromethoxy)phenyl)picolinic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:887982-16-3 SDS

887982-16-3Upstream product

887982-16-3Downstream Products

887982-16-3Relevant academic research and scientific papers

Picolinamide compound and preparation method and application thereof

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Paragraph 0073; 0075; 0096-0100; 0165; 0167; 0172-0175, (2020/08/02)

The invention discloses a picolinamide compound. The structural general formulas of the picolinamide compound are shown as formulas (I) and (II). The invention also discloses a preparation method of the picolinamide compound and application of the picolinamide compound in preparation of anti-tumor drugs. The picolinamide compound can effectively inhibit a variety of tumor cells, including human breast cancer cells, human lung cancer cells, human liver cancer cells and the like, has good anti-tumor active substances and can be used for preparing the anti-tumor drugs.

Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives

Kort, Michael E.,Atkinson, Robert N.,Thomas, James B.,Drizin, Irene,Johnson, Matthew S.,Secrest, Matthew A.,Gregg, Robert J.,Scanio, Marc J.C.,Shi, Lei,Hakeem, Ahmed H.,Matulenko, Mark A.,Chapman, Mark L.,Krambis, Michael J.,Liu, Dong,Shieh, Char-Chang,Zhang, Xufeng,Simler, Gricelda,Mikusa, Joseph P.,Zhong, Chengmin,Joshi, Shailen,Honore, Prisca,Roeloffs, Rosemarie,Werness, Stephen,Antonio, Brett,Marsh, Kennan C.,Faltynek, Connie R.,Krafte, Douglas S.,Jarvis, Michael F.,Marron, Brian E.

scheme or table, p. 6812 - 6815 (2011/01/04)

A series of aryl-substituted nicotinamide derivatives with selective inhibitory activity against the Nav1.8 sodium channel is reported. Replacement of the furan nucleus and homologation of the anilide linker in subtype-selective blocker A-803467 (1) provided potent, selective derivatives with improved aqueous solubility and oral bioavailability. Representative compounds from this series displayed efficacy in rat models of inflammatory and neuropathic pain.

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