888024-96-2Relevant academic research and scientific papers
CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR
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Paragraph 0123-0125, (2021/11/26)
The present invention relates to a novel molecule with protein tyrosine kinase inhibitory activity, and the synthesis and usage thereof. Specifically, the present invention relates to compound by formula A, pharmaceutically acceptable salts, hydrates or solvates thereof, and the synthesis and usage thereof.
Enzymatic resolution, desymmetrization, and dynamic kinetic asymmetric transformation of 1,3-cycloalkanediols
Fransson, Ann-Britt L.,Xu, Yongmei,Leijondahl, Karin,Baeckvall, Jan-E.
, p. 6309 - 6316 (2007/10/03)
An efficient desymmetrization of cis-1,3-cyclohexanediol to (1S,3R)-3-(acetoxy)-1-cyclohexanol ((R,S)-2a) was performed via Candida antarctica lipase B (CALB)-catalyzed transesterification, in high yield (up to 93%) and excellent enantioselectivity (ee's
