888030-75-9Relevant academic research and scientific papers
Efficient synthesis of 1,4-diaryl-5-methyl-1,2,3-triazole, a potential mglur1 antagonist, and the risk assessment study of arylazides
Tsuritani, Takayuki,Mizuno, Hiroo,Nonoyama, Nobuaki,Kii, Satoshi,Akao, Atsushi,Sato, Kimihiko,Yasuda, Nobuyoshi,Mase, Toshiaki
experimental part, p. 1407 - 1412 (2010/04/22)
A concise and practical synthesis of a 1,4-diaryl-5-methyl-1,2,3-triazole is described. A mGluR1 antagonist 1 was prepared with one-pot operation by the Negishi coupling reaction between two building blocks, 5-bromophthalimidine (2) and 1-aryl-5-methyl-4-
A short and efficient synthesis of isoindolin-1-ones
Tsuritani, Takayuki,Kii, Satoshi,Akao, Atsushi,Sato, Kimihiko,Nonoyama, Nobuaki,Mase, Toshiaki,Yasuda, Nobuyoshi
, p. 801 - 803 (2007/10/03)
Here, we report a short and efficient synthesis of isoindolin-1-ones. Base-induced cyclization of o-hydroxymethyl-benzamides, which was easily prepared from the corresponding phthalides and amines, led predominantly to N-alkylation in good yield. The reaction proceeded under mild conditions and bromine and nitrile substituents were tolerated. The selectivity is explained by HASB theory. Georg Thieme Verlag Stuttgart.
