888036-83-7Relevant academic research and scientific papers
Discovery of piperidine carboxamide TRPV1 antagonists
Cheung, Wing S.,Calvo, Raul R.,Tounge, Brett A.,Zhang, Sui-Po,Stone, Dennis R.,Brandt, Michael R.,Hutchinson, Tasha,Flores, Christopher M.,Player, Mark R.
experimental part, p. 4569 - 4572 (2009/04/06)
A series of piperidine carboxamides were developed as potent antagonists of the transient receptor potential vanilloid-1 (TRPV1), an emerging target for the treatment of pain. A focused library of polar head groups led to the identification of a benzoxazinone amide that afforded good potency in cell-based assays. Synthesis and a QSAR model will be presented.
