88812-63-9

Upstream product

• 1072-67-9 5-methylisoxazol-3-ylamine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1206182-28-6 1-(4-chlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1-(5-methylisoxazol-3-ylamino)pentan-3-one 
• 287918-27-8 N-(4-chlorobenzyl)-N-(5-methyl-3-isoxazolyl)amine 
• 1295478-21-5 C₁₉H₁₅ClN₄O₂S 
• 1295478-06-6 C₁₂H₁₀ClN₃OS 
• 119485-40-4 1,3-Bis-(4-chloro-phenyl)-2-(5-methyl-isoxazol-3-yl)-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine 
• 119485-31-3 1-[(4-chloro-phenyl)-(5-methyl-isoxazol-3-ylamino)-methyl]-naphthalen-2-ol 

Relevant academic research and scientific papers

Synthesis of Various Schiff Bases Containing Isoxazole Ring and Their Applications with Thioglycollic Acid and Diverse Phosphorus Reagents

A series of Schiff bases bearing isoxazole and pyrazole rings were synthesized. Application of thioglycollic acid on two selective synthesized Schiff bases afforded the corresponding thiazolidin-4-one derivatives. On the other hand, following the multicomponents one-pot Kabachnik– Fields reaction, the Schiff base generated in situ from 4-chlorobenzaldehyde and 5-methyl isoxazol-3-amine was trapped by phosphorus reagents to produce the corresponding amino phosphonates in moderate yields. However, the latter products could also be obtained in better yields (≥78%) by directly applying the dialkylphosphites to a selective synthesized Schiff base. Similarly, a series of α-aminophosphonates could be obtained from 5-chloro-3-methyl-1H-pyrazol-4-carbaldehyde, 5-methylisoxazol-3-amine, and phosphorus reagents. Moreover, applying hexaalkyl triamido phosphites to the N-(4-chlorobenzylidene)-5-methylisoxazol-3-amine in ethanol afforded methylphosphonic diamide derivatives, whereas N-((5-chloro-3-methyl-1H-pyrazol-4-yl)methylene)-5-methylisoxazol-3-amine underwent dechlorination through reaction with hexaalkyl triamido phosphites to give the respective amine derivatives.

Synthesis and antidiabetic performance of β-amino ketone containing nabumetone moiety

We wish to report the further design and improved synthesis that resulted in two series of target molecules, TM-1 and TM-2, with remarkably simplified structures containing β-amino ketone of discrete nabumetone moiety. These were obtained via a 'one-pot,

A fast and highly efficient protocol for reductive amination of aromatic aldehydes using NaBH4 and isoxazole amines in an ionic liquid medium

Reductive amination of aromatic aldehydes using NaBH4 and isoxazole amines is carried out in a Bronsted acidic ionic liquid 1-methylimidazolium tetrafluoroborate [(HMIm)BF4]. The ionic liquid plays dual roles of solvent as well as ca

Synthesis of isoxazolyl oxadiazolines and thiazolidinones

4-(5-Methyl-3-isoxazolyl)-3,5-diaryl-Δ2-1,2,4-oxadiazolines have been prepared by benzonitrile oxide addition to 3-benzalamino-5-methyl isoxazoles. The Schiff bases have been obtained by the condensation of aromatic aldehydes with 3-amino-5-met