88816-46-0

Upstream product

• 88816-45-9 4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-ethylthio-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate 

Downstream Products

• 88816-44-8 4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4S)-4-chloro-3-{1'(R)-hydroxyethyl}-2-azetidinon-1-yl]propenoate 

Relevant academic research and scientific papers

Stereoselective Synthesis of a (5R,6S)-6--2-thioxopenam Ester through a Hydroxy Group Directed Chlorinolysis

Hydroxy group directed chlorinolysis of (3S,4R)-3--4-ethylthioazetidin-2-one (4) gives predominantly the corresponding (4S)-4-chloroazetidinone (5) which is cyclised to the (5R,6S)-6--2-thioxopenam (1).

7-Oxo-4-thia-1-azabicyclo(3,2,0)heptane derivatives

Compounds of the formula Ia and their tautomers Ib STR1 in which formulae R represents a carboxyl esterifying group are described, as well as processes for their manufacture. Ia and Ib are valuable starting materials for the preparation of various derivatives substituted at position 3 that possess antibacterial properties.