88820-50-2Relevant academic research and scientific papers
Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR
Yu, Tao,Li, Ning,Wu, Chengde,Guan, Amy,Li, Yi,Peng, Zhengang,He, Miao,Li, Jie,Gong, Zhen,Huang, Lei,Gao, Bo,Hao, Dongling,Sun, Jikui,Pan, Yan,Shen, Liang,Chan, Chichung,Lu, Xiulian,Yuan, Hongyu,Li, Yongguo,Li, Jian,Chen, Shuhui
supporting information, p. 256 - 261 (2018/03/21)
The identification and lead optimization of a series of pyridopyrimidinone derivatives are described as a novel class of efficacious dual PI3K/mTOR inhibitors, resulting in the discovery of 31. Compound 31 exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation in cell assays, and good pharmacokinetic profile. Furthermore, compound 31 demonstrated in vivo efficacy in a PC-3M tumor xenograft model.
PYRIDO[1,2-a]PYRIMIDONE DERIVATIVES AS A mTOR/PI3K SUPPRESSOR
-
Paragraph 0079; 0080, (2016/10/08)
The invention discloses pyrido[1,2-a]pyrimidone derivatives as a mTOR/PI3K suppressor; and in particular, this invention relates to a compound having the formula (I) structure or its pharmaceutically acceptable salts.
1,3-Dipolar cycloaddition of 2-diazopropane to pyrimido/1,2-b/pyridazin-4-one derivatives. The synthesis of pyrazolo/4,3-d/pyrimido/1,2-b/pyridazin-4(10H)-ones, derivatives of a novel heterocyclic system
Stanovnik, Branko,Boznar, Breda,Koren, Bozidar,Petricek, Sasa,Tisler, Miha
, p. 1 - 4 (2007/10/02)
Facile regiospecific cycloaddition of 2-diazopropane (2) to the pyrimido/1,2-b/pyridazin-4-ones (1a-d), derivatives of 10?-electron heteroatomic bicyclic system, give the pyrazolo/4,3-d/pyrimido/1,2-b/pyridazin-4(10H)-ones (4a-d) in 32-52percent yields
SYNTHESIS OF SOME PYRIMIDOPYRIDAZIN-2- AND -4-ONES. STUDIES ON PYRIDAZINE COMPOUNDS, XV.
Matyus, Peter,Kasztreiner, Endre,Szilagyi, Geza,Soti, Marta,Sohar, Pal
, p. 2225 - 2228 (2007/10/02)
Some pyrimidopyridazin-2- and -4-ones were synthesized.On the basis of their spectral data the structure of some known derivatives is revised.
