888216-25-9 Usage
Uses
Used in Pharmaceutical Industry:
Ganetespib is used as an anticancer agent for its ability to inhibit heat shock protein 90, which plays a crucial role in the survival and proliferation of cancer cells. Its potent cytotoxicity against various transformed cell lines makes it a promising candidate for the treatment of both hematologic and solid tumors.
Used in Immunotherapy:
Ganetespib is used as an immunotherapy enhancer to improve the effectiveness of T-cell-mediated killing of human melanoma cells. It has shown the potential to potentiate responses to anti-CTLA4 and anti-PD1 therapies by upregulating interferon response genes, which can lead to better clinical outcomes for cancer patients.
Used in Clinical Research:
Ganetespib is utilized in multiple clinical trials to evaluate its safety, efficacy, and potential as a treatment option for various cancer types. These trials aim to determine the optimal dosing, administration, and combination therapies that can maximize the benefits of Ganetespib in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 888216-25-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,8,2,1 and 6 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 888216-25:
(8*8)+(7*8)+(6*8)+(5*2)+(4*1)+(3*6)+(2*2)+(1*5)=209
209 % 10 = 9
So 888216-25-9 is a valid CAS Registry Number.
888216-25-9Relevant academic research and scientific papers
COMBINATION THERAPY FOR TREATING CANCER
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Page/Page column 63; 67; 68, (2019/02/02)
A method of treating cancer comprising administering an effective amount of each of a chemotherapeutic agent and an Hsp90 inhibitor, either separately or as a covalent conjugate of the two, to provide a combination therapy having an enhanced therapeutic e
Improved method for preparing HSP90 inhibitor Ganetespib
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, (2018/02/04)
The invention discloses an improved method for preparing an HSP90 inhibitor Ganetespib. According to the method, raw materials in the synthesizing method are improved, certain raw materials with relatively high prices are subjected to designing synthesis
