888229-72-9Relevant academic research and scientific papers
Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors
Liu, Mei,Xin, Zhili,Clampit, Jill E.,Wang, Sanyi,Gum, Rebecca J.,Haasch, Deanna L.,Trevillyan, James M.,Abad-Zapatero, Cele,Fry, Elizabeth H.,Sham, Hing L.,Liu, Gang
, p. 2590 - 2594 (2006)
A novel class of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as c-Jun-N-terminal kinase (JNK) inhibitors is described. These compounds were synthesized via the condensation of 2-nitrobenzaldehydes and hydroxypyrazoles. The structure-activity relationships (SAR) and kinase selectivity profile of the inhibitors are also discussed. Compound 16 was identified as a potent JNK inhibitor with good cellular potency.
Synthesis and biological evaluation of some hydroxypyrazole derivatives as anti-inflammatory-antimicrobial agents
Bekhit, Adnan A.,Abdel-Rahman, Hamdy M.,Guemei, Aida A.
, p. 81 - 87 (2007/10/03)
Some hydroxypyrazole derivatives 2-7 were synthesized by cyclocondensation of the keto-ester 1 with hydrazines hydrate or substituted hydrazines followed by reduction and acylation with acetic anhydride or trifluoroacetic anhydride. The newly synthesized
