888319-05-9Relevant academic research and scientific papers
Role of the hydrogen bonding heteroatom-lys53 interaction between the p38r mitogen-activated protein (map) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors
Thaher, Bassam Abu,Koch, Pierre,Schattel, Verena,Laufer, Stefan
supporting information; experimental part, p. 2613 - 2617 (2010/02/28)
In the framework of investigating the role of heteroatoms in pyridinyl-substituted 5-membered (hetero)cycles as potential p38α MAP kinase inhibitor scaffolds, cyclopentene, pyrrole, furan, and imidazole analogues were synthesized and tested with respect t
Synthesis and SAR Studies of diarylpyrrole anticoccidial agents
Qian, Xiaoxia,Liang, Gui-Bai,Feng, Dennis,Fisher, Michael,Crumley, Tami,Rattray, Sandra,Dulski, Paula M.,Gurnett, Anne,Leavitt, Penny Sue,Liberator, Paul A.,Misura, Andrew S.,Samaras, Samantha,Tamas, Tamas,Schmatz, Dennis M.,Wyvratt, Matthew,Biftu, Tesfaye
, p. 2817 - 2821 (2007/10/03)
2-(4-Fluorophenyl)-3-(4-pyridinyl)-5-substituted pyrroles were prepared and evaluated as anticoccidial agents in both in vitro and in vivo assays. Among the compounds evaluated, the dimethylamine-substituted pyrrole 19a is the most potent inhibitor of Eimeria tenella PKG (cGMP-dependent protein kinase). Further SAR studies on the side chain of the 2-pyrrolidine nitrogen did not enhance in vivo anticoccidial activity.
