88848-51-5Relevant articles and documents
Synthesis and Antibacterial Activity of 2,2'-Dithiobis(benzamide) Derivatives against Mycobacterium Species
Okachi, Ryo,Niino, Hideki,Kitaura, Kozo,Mineura, Kazuyuki,Nakamizo, Yoshinobu,et al.
, p. 1772 - 1779 (2007/10/02)
A series of compounds, which are analogues of 2,2'-dithiobis(benzamide), were synthesized and tested for in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv including resistant strains against streptomycin, kanamycin, or isonicotinic acid hydrazide.MICs of these compounds against a typical mycobacteria, Mycobacterium kansasii and Mycobacteruim intracellulare were also examined.Structure-activity relationships were found in a series of (acyloxy)alkyl ester derivatives depending upon the length of alkyl carbon chain.The MIC of the most potent compound , 2,2'-dithiobisbenzamide> was superior or at least equivalent to streptomycin, kanamycin, and ethanbutol.All the compounds showed no cross-resistance between the current antitubercular agents.
