888490-16-2Relevant academic research and scientific papers
Three groups good, four groups bad? Atropisomerism in ortho-substituted diaryl ethers
Betson, Mark S.,Clayden, Jonathan,Worrall, Christopher P.,Peace, Simon
, p. 5803 - 5807 (2006)
(Chemical Equation Presented) Bring on the substitute: Even outside of macrocyclic structures, such as vancomycin, appropriate substitution can give rise to atropisomerism in diaryl ethers. Stereochemical stability about the Ar-OAr axis at room temperature or above is possible when neither of the rings is symmetrically substituted and when at least one ring carries an ortho tert-butyl group or equivalent.
Synthesis of multiply ortho-substituted diaryl ethers via lithiation and oxidation of a dibenzosiloxane (phenoxasilin)
Betson, Mark S.,Clayden, Jonathan
, p. 745 - 746 (2006)
Lithiation of dibenzosiloxanes (phenoxasilins or 9-silaxanthenes), followed by oxidation of the C-Si bonds, provides a versatile method for the synthesis of 2,6,2′,6′-tetrasubstituted diaryl (biaryl) ethers. Georg Thieme Verlag Stuttgart.
Hindered diarylether and diarylsulfone bisphosphine ligands: Atropisomerism and palladium complexes
Clayden, Jonathan,Fletcher, Stephen P.,Senior, James,Worrall, Christopher P.
scheme or table, p. 1355 - 1360 (2010/10/21)
Phosphines and bisphosphines derived from hindered ortho-substituted diaryl ethers and diarylsulfones by lithiation are, with appropriate substitution patterns, resolvable atropisomeric ligands which form crystalline complexes with palladium dichloride.
