888498-07-5 Usage
Uses
Used in Pharmaceutical Synthesis:
1H-Pyrrolo[2,3-b]pyridine-4-methanamine is used as a reagent in the synthesis of 2-((1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino)-5-fluoronicotinic acid via monodechlorination. This synthesized compound has potential applications in the pharmaceutical industry, particularly for the development of new drugs targeting specific diseases and conditions.
In the chemical industry, 1H-Pyrrolo[2,3-b]pyridine-4-methanamine can be utilized as a building block for the creation of various chemical compounds with diverse applications. Its unique structure allows for the formation of new molecules with potential uses in different fields, such as materials science, agrochemicals, and more.
Overall, 1H-Pyrrolo[2,3-b]pyridine-4-methanamine is a versatile compound with significant potential in both the pharmaceutical and chemical industries. Its ability to be a key intermediate in the synthesis of various compounds makes it an important asset for researchers and chemists working on the development of new drugs and chemical entities.
Check Digit Verification of cas no
The CAS Registry Mumber 888498-07-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,8,4,9 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 888498-07:
(8*8)+(7*8)+(6*8)+(5*4)+(4*9)+(3*8)+(2*0)+(1*7)=255
255 % 10 = 5
So 888498-07-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H9N3/c9-5-6-1-3-10-8-7(6)2-4-11-8/h1-4H,5,9H2,(H,10,11)
888498-07-5Relevant academic research and scientific papers
2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS
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Page/Page column 38, (2013/07/05)
Compounds having the formula I wherein A, Rla, Rlb, R2, R3, R4, R5, R6, R7, Rs, Ra, Rb, X1, X2, X3 and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders
A practical synthesis of 2-((1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino)-5- fluoronicotinic acid
Wang, Xin,Zhi, Ben,Baum, Jean,Chen, Ying,Crockett, Richard,Huang, Liang,Eisenberg, Shawn,Ng, John,Larsen, Robert,Martinelli, Mike,Reider, Paul
, p. 4021 - 4023 (2007/10/03)
A practical synthesis of a key pharmaceutical intermediate, 2-[(1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino]-5-fluoronicotinic acid (1), is described. To introduce the aminomethyl moiety of 2 via a palladium-catalyzed cyanation/reduction sequence, a regioselective chlorination of 7-azaindole via the N-oxide was developed. A highly selective monodechlorination of 2,6-dichloro-5-fluoronicotinic acid was discovered to afford the nicotinic acid 3. The two building blocks 2 and 3 were then coupled to complete the preparation of 1.
