888501-01-7Relevant academic research and scientific papers
A practical ruthenium-catalyzed cleavage of the allyl protecting group in amides, lactams, imides, and congeners
Alcaide, Benito,Almendros, Pedro,Alonso, Jose M.
, p. 2874 - 2879 (2008/02/03)
A convenient methodology for the deprotection of N-allylic amide-like moieties was developed. The first examples accounting for the ruthenium-catalyzed deallylation of amides, lactams, imides, pyrazolidones, hydantoins, and oxazolidinones have been achieved by the sequential use of Grubbs carbene (isomerization step) and RuCl3 (oxidation step). A variety of substrates, including enantiopure multifunctional β- and γ-lactams, can be employed.
