888717-49-5Relevant articles and documents
Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase
Schroeder, Gretchen M.,Chen, Xiao-Tao,Williams, David K.,Nirschl, David S.,Cai, Zhen-Wei,Wei, Donna,Tokarski, John S.,An, Yongmi,Sack, John,Chen, Zhong,Huynh, Tram,Vaccaro, Wayne,Poss, Michael,Wautlet, Barri,Gullo-Brown, Johnni,Kellar, Kristen,Manne, Veeraswamy,Hunt, John T.,Wong, Tai W.,Lombardo, Louis J.,Fargnoli, Joseph,Borzilleri, Robert M.
, p. 1945 - 1951 (2008/12/22)
An amide library derived from the pyrrolo[2,1-f][1,2,4]triazine scaffold led to the identification of modest inhibitors of Met kinase activity. Introduction of polar side chains at C-6 of the pyrrolotriazine core provided significant improvements in in vi
