888734-47-2Relevant academic research and scientific papers
SYSTEMIC AND INTRATHECAL EFFECTS OF A NOVEL SERIES OF PHOSPHOLIPASE A2 INHIBITORS ON HYPERALGESIA AND SPINAL PGE2 RELEASE
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Page/Page column 19, (2008/06/13)
Phospholipase A2 (PLA2) forins are expressed in spinal cord whose inhibition induces a potent antihyperalgesia. PLA2 inhibitor compounds are provided that include a common motif consisting of a 2-oxoamide with a hydrocarbo
Differential inhibition of group IVA and group VIA phospholipases A 2 by 2-oxoamides
Stephens, Daren,Barbayianni, Efrosini,Constantinou-Kokotou, Violetta,Peristeraki, Anna,Six, David A.,Cooper, Jennifer,Harkewicz, Richard,Deems, Raymond A.,Dennis, Edward A.,Kokotos, George
, p. 2821 - 2828 (2007/10/03)
Inhibitors of the Group IVA phospholipase A2 (GIVA CPLA 2) and GVIA iPLA2 are useful tools for defining the roles of these enzymes in cellular signaling and inflammation. We have developed inhibitors of GVIA iPLA2/su
