888788-38-3

Upstream product

• 17791-52-5 N-(tert-butoxycarbonyl)-L-histidine 
• 13726-76-6 t-butyloxycarbonyl-L-arginine 
• 888788-12-3 (S)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-[(2R,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-(2-tritylsulfanyl-acetylamino)-tetrahydro-pyran-2-yloxy]-propionic acid allyl ester 
• 888788-08-7 (S)-3-((2R,3R,4R,5S,6R)-4,5-Diacetoxy-6-acetoxymethyl-3-amino-tetrahydro-pyran-2-yloxy)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid allyl ester 
• 888788-34-9 Ac-Leu-Tyr-Arg-Ala-His-S(CH₂)2CONH₂ 
• 888788-14-5 Acetic acid (2R,3S,4R,5R,6R)-3-acetoxy-2-acetoxymethyl-6-[(S)-2-(2-tert-butoxycarbonylamino-acetylamino)-2-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-ethoxy]-5-(2-tritylsulfanyl-acetylamino)-tetrahydro-pyran-4-yl ester 
• 888788-10-1 6-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(allyloxy)-3-oxopropoxy)-2-(acetoxymethyl)-5-(2-tritylmercaptoacetamido)tetrahydro-2H-pyran-3,4-diyl diacetate 
• 888788-16-7 ({(S)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-6-hydroxymethyl-3-(2-tritylsulfanyl-acetylamino)-tetrahydro-pyran-2-yloxy]-ethylcarbamoyl}-methyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

METHOD OF PREPARING GLYCOPEPTIDES

A method is provided for the synthesis of glycopeptides using a sugar assisted ligation strategy, wherein an N-terminal peptide portion in the form of a thioester is coopled with a C-terminal peptide portion bearing a carbohydrate moiety comprising a thiol group.

Sugar-assisted glycopeptide ligation

The chemical synthesis of glycopeptides and glycoproteins from readily available materials presents an attractive route to homogeneous products for structural and functional studies. Chemical synthesis of glycopeptides and glycoproteins based on native chemical ligation represents one of the useful methods for the synthesis of natural glycopeptide structures. Here we describe a method that allows for the synthesis of glycopeptides from cysteine-free peptides. This method utilizes a peptide thioester and a glycopeptide in which the sugar moiety is modified with a thiol handle at the C-2 position. Upon completion of the ligation reaction, the thiol handle can be reduced with H2/metal to the acetamide moiety, furnishing the unmodified glycopeptides. Together, this sequence of reactions displays an attractive potential in glycopeptides and glycoproteins synthesis. Copyright