88885-44-3Relevant academic research and scientific papers
Antifungal S-ethers of 2-aryl-3-mercapto-1-(1H-1,2,4-triazol-1-yl) propan-2-ols and corresponding sulfoxides and sulfones
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, (2008/06/13)
Compounds of the general formula: STR1 wherein R is naphthyl, biphenylyl, phenyl or substituted phenyl; n is 0, 1 or 2; and R1 is H, C1-6 alkyl, C3-7 cycloalkyl, C2-4 alkanoyl, or C1-2 alkyl substituted by C2-4 alkenyl with the provisos that when R1 is H or C2-4 alkanoyl, n is 0; and when n is 2, R1 is C1-3 alkyl; and their pharmaceutically acceptable salts are antifungal agents useful in combatting fungal infections in animals, including humans.
Antifungal S-arylmethyl- and S-heterocyclylmethyl ethers of 2-aryl-3-mercapto-1-(1H-1,2,4-triazol-1-yl) propan-2-ols
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, (2008/06/13)
Compounds of the formula: STR1 wherein Ar is phenyl substituted by from 1 to 3 substituents, each substituent being independently halo or CF3 ; n is 0 or 1; and R is a phenyl or a phenyl group substituted by from 1 to 3 substituents, each substituent being independently halo, CF3, C1 -C4 alkoxy, C2 -C5 alkoxy-carbonyl or C1 -C4 alkylthio, or a 5 or 6 membered aromatic heterocyclic group which may optionally be substituted; and their pharmaceutically acceptable salts are antifungal agents useful in combatting fungal infections in humans.
Triazole antifungal agents
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, (2008/06/13)
Triazole antifungal agents of the formula: STR1 and their O-esters and O-ethers, where R is a phenyl group optionally substituted by 1 to 3 substituents each independently selected from halo, CF3, C1 -C4 alkyl and C1 -C4 alkoxy; R1 is selected from (a) STR2 (C1 -C4 alkyl), (b) --SO2 (C1 -C4 alkyl), (C) --SO2 NR2 R3 where either R2 and R3 are both C1 -C4 alkyl, or R2 and R3 together with the N atom to which they are attached represent piperidino, (d) --NHSO2 (C1 -C4 alkyl) and (e) --CONR4 R5 where either R4 is H or C1 -C4 alkyl and R5 is C1 -C4 alkyl, or R4 and R5 together with the N atom to which they are attached represent piperidino; and n is 1 or 2 with the proviso that n is 2 when R1 is --NHSO2 (C1 -C4 alkyl); and their pharmaceutically acceptable salts. The compounds are useful as human and agricultural fungicides.
