888854-97-5Relevant articles and documents
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors
Cai, Zhen-Wei,Wei, Donna,Schroeder, Gretchen M.,Cornelius, Lyndon A.M.,Kim, Kyoung,Chen, Xiao-Tao,Schmidt, Robert J.,Williams, David K.,Tokarski, John S.,An, Yongmi,Sack, John S.,Manne, Veeraswamy,Kamath, Amrita,Zhang, Yueping,Marathe, Punit,Hunt, John T.,Lombardo, Louis J.,Fargnoli, Joseph,Borzilleri, Robert M.
scheme or table, p. 3224 - 3229 (2009/04/06)
A series of acylurea analogs derived from pyrrolopyridine and aminopyridine scaffolds were identified as potent inhibitors of Met kinase activity. The SAR at various positions of the two kinase scaffolds was investigated. These studies led to the discover
