888959-54-4Relevant articles and documents
Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity
Ferguson, Colin G.,Bigman, Cleve S.,Richardson, Robyn D.,Van Meeteren, Laurens A.,Moolenaar, Wouter H.,Prestwich, Glenn D.
, p. 2023 - 2026 (2007/10/03)
Lysophospholipase D (lysoPLD), also known as autotaxin (ATX), is an important source of the potent mitogen lysophosphatidic acid (LPA). Two fluorogenic substrate analogues for lysoPLD were synthesized in nine steps from (S)-PMB-glycerol. The substrates (FS-2 and FS-3) show significant increases in fluorescence when treated with recombinant ATX and have potential applications in screening for this emerging drug target.