88899-02-9

Basic information

• Product Name: 2,4,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one
• Synonyms: 2,4,8-Trihydroxy-1-tetralone
• CAS NO: 88899-02-9
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• Mol File: 88899-02-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 446.2°C at 760 mmHg
• Flash Point: 237.8°C
• Density: 1.551g/cm³
• Vapor Pressure: 9.57E-09mmHg at 25°C
• Refractive Index: 1.697
• CAS DataBase Reference: 2,4,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one(88899-02-9)
• EPA Substance Registry System: 2,4,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one(88899-02-9)

Safety Data

• Hazardous Substances Data: 88899-02-9(Hazardous Substances Data)

Upstream product

• 51114-98-8 isosclerone 
• 110815-46-8 4,8-Bis-(tetrahydro-pyran-2-yloxy)-3,4-dihydro-2H-naphthalen-1-one 
• 6312-53-4 juglone 
• 110815-47-9 (2S,4R)-2-Hydroxy-4,8-bis-(tetrahydro-pyran-2-yloxy)-3,4-dihydro-2H-naphthalen-1-one 
• 110815-47-9 (2R,4R)-2-Hydroxy-4,8-bis-(tetrahydro-pyran-2-yloxy)-3,4-dihydro-2H-naphthalen-1-one 
• 524002-68-4 1,4,5-tris{[(tert-butyl)dimethylsilyl]oxy}-1,2-dihydroxynaphthalene 
• 524002-76-4 (-)-(2R,4R)-4,8-bis{[(tert-butyl)dimethylsilyl]oxy}-3,4-dihydro-2-hydroxynaphthalen-1(2H)-one 

Relevant articles and documents

Asymmetric synthesis of the cis- and trans-3,4-dihydro-2,4,8-trihydroxynaphthalen-1(2H)-ones

A short and efficient protocol for the asymmetric synthesis of cis- and trans-3,4-dihydro-2,4,8-trihydroxynaphthalen-1(2H)-one (1 and 2, resp.) is described, with a phthalide annulation as the key step. Introduction of a OH substituent at position 2 was performed by Sharpless dihydroxylation of a silyl enol ether or by means of an N-sulfonyloxaziridine. The absolute configuration of each isomer was determined via Mosherester derivatives. By comparison with previously recorded CD spectra of our natural sample, we established that the natural trans- and cis-isomers from Ceratocystis fimbriata sp. platani were the (-)-(2S,4S)-isomer (-)-2 and the (+)-(2S,4R)-isomer (+)-1, respectively.