88899-22-3 Usage
General Description
"BZ-PHE-VAL-ARG-AMC" is a peptide substrate used in enzymatic assays to measure the activity of proteolytic enzymes such as trypsin and chymotrypsin. The BZ represents the benzyoyl moiety on the N-terminus of the peptide, and AMC stands for aminomethylcoumarin, a fluorogenic group that emits strong fluorescence upon cleavage from the peptide backbone. The sequence PHE-VAL-ARG is the specific substrate that is cleaved by the enzyme, and the presence of the AMC group allows for the measurement and quantification of the enzymatic activity. This peptide substrate is commonly used in research and pharmaceutical development to study the activity of proteolytic enzymes and their inhibitors.
Check Digit Verification of cas no
The CAS Registry Mumber 88899-22-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,8,9 and 9 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 88899-22:
(7*8)+(6*8)+(5*8)+(4*9)+(3*9)+(2*2)+(1*2)=213
213 % 10 = 3
So 88899-22-3 is a valid CAS Registry Number.
88899-22-3Relevant articles and documents
A novel solid-phase linker strategy for the side-chain anchoring of arginine: an expeditious route to arginine 7-amido-4-methylcoumarins
Beythien, Joerg,Barthélémy, Sophie,Schneeberger, Peter,White, Peter D.
, p. 3009 - 3012 (2006)
A novel linker strategy for the efficient side-chain anchoring of arginine is described. The utility of this approach was demonstrated by the facile synthesis of arginine-specific fluorogenic peptide substrates by standard Fmoc solid phase peptide synthesis methods.
