88901-39-7 Usage
Description
Mogroside I E1, a triterpenoid saponin derived from the fruits of Siraitia grosvenorii, commonly known as monk fruit, is a natural zero-calorie sweetener that is 230-425 times sweeter than sucrose. It exhibits a range of pharmacological properties, such as antioxidant, anti-inflammatory, and anti-diabetic effects, and is being investigated for its potential anti-cancer and neuroprotective properties. With its intense sweetness and health benefits, Mogroside I E1 is emerging as a promising alternative to artificial sweeteners and sugar in various food and beverage products.
Uses
Used in Food and Beverage Industry:
Mogroside I E1 is used as a natural sweetener for its intense sweetness and zero-calorie content, making it an ideal alternative to sugar and artificial sweeteners in various food and beverage products.
Used in Pharmaceutical Industry:
Mogroside I E1 is used as a potential therapeutic agent for its antioxidant, anti-inflammatory, and anti-diabetic properties, offering potential health benefits in the development of medications for related conditions.
Used in Anticancer Applications:
Mogroside I E1 is being studied for its potential as an anticancer agent, with research exploring its effects on various types of cancer and its possible synergistic benefits when combined with conventional chemotherapeutic drugs.
Used in Neuroprotective Applications:
Mogroside I E1 is being investigated for its potential neuroprotective properties, with research examining its ability to protect against neurodegenerative diseases and promote brain health.
Check Digit Verification of cas no
The CAS Registry Mumber 88901-39-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,9,0 and 1 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 88901-39:
(7*8)+(6*8)+(5*9)+(4*0)+(3*1)+(2*3)+(1*9)=167
167 % 10 = 7
So 88901-39-7 is a valid CAS Registry Number.
88901-39-7Relevant articles and documents
Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1
Cai, Yi,Li, Jiao,Lin, Jianping,Liu, Cui,Liu, Pi,Liu, Weidong,Ma, Yanhe,Mu, Shicheng,Shang, Na,Sun, Yuanxia,Yang, Jiangang,Zhu, Yueming
, p. 3629 - 3639 (2020)
Triterpene O-glycosylation has attracted significant interest from the pharmaceutical industry as a valuable means for drug design and development. Plant glycosyltransferases, which catalyze this glycosylation reaction, play a key step in preparing structure diverse and valuable triterpene glycosides. However, this class of enzymes usually suffers from low catalytic efficiency. To address this problem, triterpene glycosyltransferase UGT74AC1 from Siraitia grosvenorii was chosen and its crystal structure was solved and employed as the molecular basis to implement directed evolution and sequence/structure-based engineering. Several resultant uridine diphosphate (UDP) glycosyltransferases (UGTs) variants exhibit a 102- to 104-fold improvement in catalytic efficiency for triterpene glycosylation. Especially, one variant exhibited up to 4.17 × 104-fold increase in catalytic efficiency toward mogrol and 1.53 × 104-fold increase to UDP-glucose, respectively. Moreover, the mutants also displayed extended substrate promiscuity compared with wild-type enzyme and conserved regioselectivity. Based on the results of molecular docking and molecular dynamics simulations, it was proposed that the improved enzymatic activity and substrate promiscuity were likely owing to the stable hydrophobic interactions and favorite conformations between the enzyme and substrates. This work has also laid a foundation for the engineering of other plant UGTs for their practical application to the synthesis of valuable triterpene saponins.
