88906-20-1Relevant academic research and scientific papers
The first example of asymmetric hydrogenation of imines with Co 2(CO)8/(R)-BINAP as catalytic precursor
Amézquita-Valencia, Manuel,Cabrera, Armando
, p. 17 - 21 (2013)
The first example of asymmetric hydrogenation of imines using Co 2(CO)8/(R)-BINAP/H2/CO system was developed. The reaction conditions were screened with a wide range of N-aryl benzophenone ketimines, obtaining products with excellent yields and good enantiomeric excess. Moreover, a pathway is suggested based on the isolation and characterization of several catalyst intermediates.
Taking the F out of FLP: Simple lewis acid-base pairs for mild reductions with neutral boranes via borenium ion catalysis
Eisenberger, Patrick,Bailey, Adrian M.,Crudden, Cathleen M.
, p. 17384 - 17387 (2013/01/15)
Discrete three-coordinate borenium salts 1c and 1d are accessed by cooperative Lewis acid-base pair-mediated heterolytic splitting of the B-H bond in pinacolborane by B(C6F5)3DABCO and Ph 3C+/DABCO, respectively. The resulting salts are competent catalysts in the reduction of a broad range of imines and can be generated in situ. Moreover, a mechanistic framework for borenium catalysis based on experimental evidence is proposed. The reaction is suggested to proceed by borenium activation of the imine substrate followed by counterintuitive hydride delivery from HBPin (with the assistance of DABCO) rather than from the HB(C6F5)3- anion, contrary to typical mechanisms of reduction in FLP systems.
